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Y học lâm sàng

Nguyễn Thị Chiêm, Cấn Văn Mão, Phạm Minh Đàm, Vi Thị Phương Lan, Lưu Thị Thu Phương(1), Đinh Trọng Hà, Hisao Nishijo, Trần Hải Anh

Nghiên cứu hoạt động vận động, tương tác xã hội trên chuột nhắt được tiêm thuốc tác động lên hệ Glutamatergic

Research on locomotion, social interaction in mice injected with a substance affecting glutamatergic system

Sinh lý học Việt Nam

2012

2

32-41

1859-2376

The study was conducted on 60 healthy male white mice, aged 8-10 weeks, and weighed 20-30 g. The purposeof the research was to evaluate the locomotor activities and social interactions in mice that were injected with ketamine, a drug affecting glutamatergic system. Mice were divided into two groups. Control group consisted of 30 mice were injected with NaCl 0.9 percent dosed 10 ml/kg/day for 14 consecutive days. Ketamine group consisted of 30 mice were injected with ketamine dosed 20mg/kg/day for 14 days continuously. The results showed that the numberof entries,exits from the centerzone, the numberof passingthroughthe middleline in the locomotive chamber, time of interactions in the interative chamber and the number of entries, exits from the open arm and center zone in cross maze in the ketamine group were lower than those before injection and those of the control group.

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