The objective of this study is to find out the relationship from information disclosure to the profitability of companies listed on the Vietnam Stock Exchange. The study uses data of all companies listed on both HOSE and HNX (except for companies in the financial sector) from 2017-2019 with 1,978 observations. The research results show that the average level of information disclosure of companies is 68.87%. With the estimated results from the regression method, the percentile regression and the quartile regression using the instrumental variables show clear effects on the profit margin of information disclosure for companies with high financial ratios, returns from 4.21% (in the 25% percentile) will inherit the full disclosure results the most, the larger the percentiles are, the greater the impact of disclosure on margins become less and less significant for the group of companies with margins from 17.54% (in the 75% percentile). In addition, the study also shows that there are other effects on corporate profitability from some other control variables in the model such as duality, total assets, and financial leverage.