Ischemic stroke occurring after primary percutaneous coronary intervention (PCI) is rare but has severe consequences. The rate of serious illness and in - hospital mortality was higher in this group of patients than in patients with other procedure - related complications. We report a case study with an acute ischemic stroke complication after primary percutaneous coronary intervention. Diagnosing a patient with a stroke while the patient is still on the operating table is very important. The practitioner should check the patient’s condition after key steps of the interventional procedure such as thrombectomy. Suppose an ischemic stroke is suspected while the femoral artery catheter is still in the lumen. In that case, immediate cerebral angiography is a possible solution by the interventional physician to confirm the diagnosis and the morphology of thrombosis, degree of embolism. In this situation, mechanical thrombectomy and arterial thrombolytic agents such as alteplase may be the treatment of choice. Routine thrombectomy should be avoided and done with care to help prevent acute ischemic stroke complications. Early identification of suspected symptoms right after completing the procedure as well as during follow-up to accurately assess the treatment window time and coordinate multiple specialist groups.