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  • Công bố khoa học và công nghệ Việt Nam

76.29.51

Y học lâm sàng

Cấn Văn Mão, Vũ Thị Chiêm, Vi Thị Phương Lan, Phạm Minh Đàm, Lưu Thị Thu Phương(1), Hisao Nishijo, Trần Hải Anh

Nghiên cứu học tập, trí nhớ trên động vật được tiêm thuốc gây mô hình thực nghiệm bệnh tâm thần phân liệt

Learning and memory in animals injected with a drug to induce modeled schizophrenia

Sinh lý học Việt Nam

2012

3

43-49

1859-2376

The research was conducted on 60 healthy male white mice, aged 8-10 weeks, and weighted 20-30 g. The aim of study was to assess the learning ability and memory in animals injected with drugs affecting glutamatergic system (ketamine). Animals were divided into two groups. A control group consisted of 30 mice injected. with NaCI 0.9 percent dosed 10 ml/ kg/day for 14 consecutive days. An experimental group of 30 mice injected with ketamine dosed 20 mg/kg/day for 14 consecutive days. The results showed that traveled distance and swimming time since mice placed in a water maze to find the platform as well as the time to find food in a food maze were shorten over time. However, those in the control group reduced gradually and faster, while those of the ketamine group were unstable and decreased more slowly.

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