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Trần Thị Phương Nhung, Trần Thị Thanh Nhã(1), Trương Thị Mỹ Úc, Vũ Thị Ánh Tuyết, Nguyễn Trường Sơn, Nguyễn Thị Kim Trinh, Quảng Trần Phương Tuyên, Tô Minh Quân, Trần Hoài Ninh, Trần Phạm Thúy Vy

Khả năng ngăn ngừa và chống viêm của chiết xuất nước hành đen trên mô hình chuột được gây viêm khớp dạng thấp với FCA

Prevention and anti-inflammatory potential of crude aqueous extracts of black onion on fca-induced rheumatoid arthritis in mice

Tạp chí Khoa học và Công nghệ - ĐH Công nghiệp TP. Hồ Chí Minh

2022

01

93-104

2525-2267

Viêm khớp dạng thấp, Hành đen, Chiết xuất, Chuột thực nghiệm, FCA, Kháng viêm

Rheumatoid arthritis, Black shallot extract, Freund Complete’s Adjuvant

Viêm khớp dạng thấp là một rối loạn viêm mãn tính chủ yếu tấn công các khớp linh hoạt. Hành đen, sản phẩm chế biến mới từ hành tươi (Allium cepa L.), có nhiều đặc tính dược lý và sinh học như chống oxy hóa, chống viêm và ung thư. Tuy nhiên khả năng ngăn ngừa và chống viêm của chiết xuất hành đen đối với bệnh viêm khớp vẫn chưa được báo cáo. Do đó, chúng tôi đã đánh giá chiết xuất nước hành đen (AeBA) với liều lượng (200, 300, 400 mg/kg thể trọng), thuốc tham chiếu Mobic (7,5 mg/50kg thể trọng) sử dụng mô hình chuột bị viêm khớp do FCA (0,1 ml/con chuột). Trọng lượng cơ thể, nhiệt độ bàn chân sau, chỉ số khớp, trọng lượng cơ quan, thông số huyết học, sinh hóa, mô bệnh khớp mắt cá chân được sử dụng làm tiêu chí để đánh giá tác động của AeBA đối với tình trạng viêm khớp. Kết quả, AeBA (400 mg/kg thể trọng) thể hiện hoạt tính ngăn ngừa và chống viêm thông qua việc cải thiện các chỉ tiêu khảo sát. Những kết quả này chứng minh rằng AeBA có tác dụng chống viêm. AeBA là ứng cử viên tiềm năng cho liệu pháp điều trị viêm khớp.

Rheumatoid arthritis is a chronic disease that mainly affects flexible (synovial) joints. Black shallot, a new processing product from fresh shallot (Allium cepa L.), possesses many pharmacological and biological properties, such as antioxidant, anti-inflammatory and anticancer activities. However, prevention and anti-inflammatory potential of black shallot extracts has not yet been reported on arthritis. Thus, we evaluated the effect of aqueous extract of black shallot (AeBA) on FCA (0.1ml/mouse) induced arthritis mice models with a range of doses (200, 300 and 400 mg/kg body weight) in comparison with Mobic (7.5 mg/50 kg body weight) as the reference. Body weight, temperature of the hind feet, arthritic index, relative organ weights, haematological and biochemical parameters, and histological features of ankle joints were used for assessing the effect of AeBA on joint inflammation. The dose of 400 mg AeBA /kg body weight resulted in an improvement of all the testing parameters, demonstrating the prevention and antiinflammatory potential of the extract. These results indicate that AeBA might be a potential candidate for therapeutic rheumatoid arthritis treatment.

TTKHCNQG, CVv 449

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