The problem of flood forecasting for disaster mitigation and water risk management is an increasingly urgent task due to the increasingly scarce water resources in Vietnam, while tools, calculation models, and flood forecasting technologies in our country are still limited. This paper will present the results achieved in the research and development of a modern distributed hydrological a mathematical model tool (MARINE) to solve the flood forecasting problem. The results achieved when implementing the pilot application to the Nam Mu River basin, with a 19–year data set, showed that the MARINE model after being developed has produced quite good simulation results, the system has simulated the hydrograph of flood, the error of flood peaks and the time of peak appearance is quite reasonable. The optimal parameters control technique (MSCE_UA) has significantly improved the system simulation quality of the MARINE model, with the NASH index is 0.67. The success of this research has significantly improved the feasibility of the MARINE.