Mối tương quan giữa nồng độ HBsAg, HBV DNA trong theo dõi điều trị viêm gan B mạn

Chỉ số đề mục

76.29.34

Lĩnh vực nghiên cứu

Y học lâm sàng

Dạng tài liệu

Tác giả

Nguyễn Thị Hoa, Trần Ngọc ánh, Nguyễn Thị Thủy⁽¹⁾

Nhan đề

Mối tương quan giữa nồng độ HBsAg, HBV DNA trong theo dõi điều trị viêm gan B mạn

Nhan đề tiếng anh

Correlation of quantitative assay of HbsAg and HBV DNA levels during chronic HBV treatment

Nguồn trích

Y học Việt Nam

Năm xuất bản

2014

Số

2

Trang

46-50

ISSN

1859-1868

Từ khóa

Viêm gan B mạn tính, Nồng độ HBsAg, Nồng độ HBV DNA, Đáp ứng virus một phần, Nghiên cứu

Từ khóa tiếng anh

Tóm tắt

Tóm tắt tiếng anh

Viral load is used for the diagnosis and monitoring the treatment of chronic hepatitis B (CHB). Previous studies suggest that quantitative HbsAg studied can be a surrogate marker. the study aimed to Investigate whether quantitative HbsAg correlates HBV DNA levels during CHB treatment. The study included 60 patients with CHB. They were given TDF 300mg/day, and serum samples were obtained in weeks 0,12,24. HBV DNA was measured by realtime PCR. Quantitative HbsAg was studied by Roche elecsys HbsAg II quant.HBV DNA levels were measured as follows 7,14; 3,34; 2,09 log10UI/ml. The corresponding HbsAg quantitation results were. 4,79; 4,37; 4,13 logl10UI/ml They showed a significant correlation (r=0,33 at week 0, r=0,51-week 12, r=0,54-week 24). Serum HbsAg levels markedly decreases in sustained responders with meand decreases of 0,59 and 0,6 logloUI/ml at week 12,24. In conclusion, HbsAg studied correlates with HBV DNA and can be a surrogate marker during the monitoring of the efficacy of HBV treatment.

Kí hiệu kho

TTKHCNQG, CVv 46

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