The surface water is increasingly polluted due to natural hazards and human activities. Therefore, the monitoring, assessing, and controlling of surface water quality is a critical responsibility. This study was conducted to collect data on surface water quality from 2000 to 2020 and individual stakeholders were interviewed in the following affected areas: (i) residential area (Ninh Kieu district), (ii) industrial zone (Binh Thuy district), (iii) fruit area (Phong Dien district), and (iv) rice field area (O Mon, Thoi Lai, and Co Do district). The results show that sampling collection times were slightly different, but the surface water quality slightly decreased in December, for example, the pH and temperature had not differed among the 4 study areas. Surface water quality was the best in the fruit area, whereas it was the worst in the residential area. The surface water quality has decreased as a result of poor wastewater management by companies, and industrial parks. Stakeholders discharged the wastes directly into the river, and the fertilizers and pesticides were used excessively, therefore it is necessary to treat and manage the waste sources in the near future.