Using bone marrow stem cell in treabnent of bone and joint diseases has been interested to research. Objectives: 1) evaluate the effect of autologous bone marrow stem cell in treabnent of long bone nouinions, aseptic femoral head osteonecrosis and limb lengthening; 2) determine the relationship between the number of stem cells grafted and the clinical outcome. Subjects: 142 patients with long bone nonunions, 50 patients with aseptic femoral head osteonecrosis and 36 patients with limbs lengthened by llizarov's prindple. Methods: 20-30 milliliters of autologous bone marrow stem cell mass were separated from 250-350 milliliters of aspirated bone marrow fluid and injected in to sites of bone lesion. Results: 84.5 percent patients with bone nouinions achieved bone union with bone healing time of 19,8 + or - 9,5 weeks; 82 percent patients with aseptic femoral head osteonecrosis had good outcome(based on Harris criteria); the bone healing time for 1 centimeter of length in patients with limbs lengthened and bone marrow stem cell grafted was 29,5 + or - 4,5 days, significantly shorter when compared with patients without grafting bone marrow stem cell. Conclusions: autologous bone marrow stem cell grafting was a safe and effective method in treabnent of long bone nonunion, aseptic femoral head osteonecrosis and limb lengthening. There was relationship between the numbers of stem cell grafted and the clinical outcome.
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