Chlorogenic acids (CGAs) constitute a large family of esters and are present in many medicinal plants. CGAs play an important role in modern traditional medicine, but only some of this family’s pure compoundshave been thoroughly researched and shown good pharmaceutical effects. The green coffee beans (CFX)contained ~ 11% of CGAs depending on the species, cultivation and harvested conditions. The quatitativeanalysis could show the presence of separate CGA compounds. Instead of using expensive pure CGA compounds as analysis standard, the HRMS-QTOF detector could unequivocally assign the compound identity while the coupled HPLC could effectively separate the CGAs . In this study, the HPLC-QTOF technique was used to qualitatively determine the CGAs present in the green coffee beans. Ít showed that the CFX harvested in different times have the same CGAs profiling.