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Y học lâm sàng

Vương Thị Ngọc Lan(1), Võ Minh Tuấn

So sánh giá trị dự đoán của AMH, FSH và AFC với đáp ứng nhiều trong kích thích buồng trứng thụ tinh ống nghiệm

Comparison of the accuracies of AMH, FSH, and AFC for predicting hyper-response in in-vitro fertilization

Y học thực hành

2013

12

63-65

1859-1663

Introduction: Hyper-response is a primary risk factor of ovarian hyperstimulation syndrome (OHSS), a serious side-effect of controlled ovarian stimulation (COS). Prediction of hyper-response is vital for choosing the appropriate COS protocol to avoid OHSS in these patients. Objectives: To compare the accuracy of AMH, FSH, and AFC and to indentify their cut-offs for predicting hyper-response. Methods: A prospective cohort study was conducted on 820 patients. Each patient had AMH, FSH and AFC measured on cycle day 2. Hyper-response was diagnosed when patients had 15 oocytes retrieved. Results: The rate of hyper-response was 21,8 percent. The AMH test was the most accurate in predicting hyperresponse, followed by AFC, and the least accurate predictive test was the FSH. AMH 3.57 ng/ml predicted hyper-response with a sensitivity of 83.7 percent and specificity of 79.8 percent. Conclusion: AMH has the highest accuracy in predicting hyper-response.

TTKHCNQG, CVv 57