Objectives: To Evaluate the effects of lercanidipne versus amlodipine in hypertensive patients with cerebral ischemic stroke by ambulatory blood pressure monitoring (ABPM). Methods: 104 hypertensive patients with cerebral ischemic stroke who were taken ABPM with every 30 minutes interval for during daytime (6am-10pm) and every 60 minutes interval overnight (10pm-6am)had sufficiently the criteria (24h mean blood pressure or = 130/90 mmHg). Theses patients received antihypertensive treatment and were divided randomly in two parallel groups study, 52 patients (30 men, 22 women, mean age 64.6 years) received lercanidipin 20 mg/day and 52 patients (30 men, 22 women mean age 65.4 years) receivedamlodipine 10 mg/day. Every patient was taken ABPM two times, first times in acute phase of cerebral ischemic stroke, second times after 4 weeks taking drugs. Results: The level of reduction in 24 hours and nighttime systolic/diastolic blood pressure of lercanidipine was lower significantly versus amlodipine (17.0 / 8.2 13.7 / 7.l mmHg versus to 23.4 / 12.7 and 23.7 / 13.8 mmHg, p 0.05 and 0.01 respectively). Normalized and responsesrate on ABPM of the two drugs were similar (34.6 percent and 30.8 percent for lercanidipine versus 48.1 percent and 44.2 percent for amlodipine p 0.05 respectively). Trough/peak ratios of lercanidipine were 0.61 for systolic and 0.52 for diastolic blood pressure; that of amlodipine were 0.75 for systolic and 0.73 for diasystolic blood pressure. Smoothness index of lercanidipine were 0.79 for systolic and 0.57 for diastolic blood pressure; that of amlodipine were 1.22 for systolic and 1.0 for diasystolic blood pressure in patients having cerebral ischemic stroke with hypertension. The side effects' rate of lercanidipine was lower significantly versus amlodipine (5.7 percent vs. 19.2 percent, P 0.05). Conclusion: The level of reduction in 24 hours and the nighttime systolic/diastolic blood pressure of lercanidipine was lower significantly than amlodipine. The rate of side effects of lercanidipine was significantly lower than with amlodipine. Lercanidipine reduces early morning surge of blood pressure more significantly than before treatment. Should use lercanidipine in patients with cerebral ischemic stroke having hypertension.
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