Intestinal metaplasia at the gastroesophageal junction, known as Barrett's esophagus, is one of the severe complications of GERD and considered as premalignancy condition of esophagus adenocarcinoma. Risky factors that related with this condition have not clearly been confirmed. Aims: To assess state and relationship between intestinal metaplasia and Helicobacter Pylori at the gastro-esophageal junction in patients with GERD. Patients and methods: 152 patients with GERD at the No.108 Hospital, aged 18-70 years, underwent upper GI endoscopy and biopsies (4 samples from GJ) to assess intestinal metaplasia and H. pylori infection.Results: Intestinal metaplasia was found in 19.7 percent of patients; dysplasia was 1,3 percent and esophageal adenocarcinoma was 2.6 percent. Intestinal metaplasia below Z line was found in 9.9 percent of cases, above it was 5.9 percent and at both sites was 3.9 percent. The rate of H. pylori infection at GJ was 13.2 percent (below Z line - 11.2 percent and above it - 0.7 percent). The rate of intestinal metaplasia of the patients with H. pylori-positive (10 percent) was lower than those with H. pylori- negative (21.2 percent),but the difference was not significant (p 0.05). There was no dyplasia in the patients with H. pylori-positive. Conclusions: Intestinal metaplasia at gastroesophageal junction is common in GERD patients. However, the research did not find the correlation between this condition with H. pylori infection at gastroesophageal junction.
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