TỔNG HỢP MỘT SỐ DẪN XUẤT MỚI CHỨA THIENO[3,2-b]THIOPHENE THÔNG QUA PHẢN ỨNG GHÉP CHÉO HOẠT HOÁ TRỰC TIẾP LIÊN KẾT C-H

Chỉ số đề mục

Lĩnh vực nghiên cứu

Khoa học y, dược

Dạng tài liệu

BB

Tác giả

Nguyễn Hiển, Dương Quốc Hoàn⁽¹⁾, Nguyễn Thị Thu Hiền

Nhan đề

TỔNG HỢP MỘT SỐ DẪN XUẤT MỚI CHỨA THIENO[3,2-b]THIOPHENE THÔNG QUA PHẢN ỨNG GHÉP CHÉO HOẠT HOÁ TRỰC TIẾP LIÊN KẾT C-H

Nhan đề tiếng anh

SYNTHESIS OF SOME NEW THIENO[3,2-b]THIOPHENE CONTAINING DERIVATIVES VIA C-H ACTIVATION CROSS COUPLING REACTION

Nguồn trích

Tạp chí Phân tích Hóa, Lý và Sinh học

Năm xuất bản

2022

Số

4

Trang

153

ISSN

Từ khóa

Từ khóa tiếng anh

Tóm tắt

Compounds containing thieno[3,2-b]thiophene generally exhibit good fluorescent properties and havean important role in the labeling of biological products. In our study, 04 derivatives containing thieno[3,2-b]thiophene structure were synthesized through cross-coupling reaction that directly activates the C-H bond using palladium catalyst. The different reaction conditions were investigated using two catalyst platforms Pd(OAc)2 and PdCl(C3H5)(dppb). Experimental results show that: ester A(1.5 equiv), A0 (1.0 equiv), PdCl(C3H5)(dppb), 3 mol%, KOAc (5 equiv) in DMAC solvent (1mL/0.02 mmol ester A), temperature 1300C and reaction time 24h is the best condition for the coupling reaction. The structures of the obtained derivatives were determined by 1D, 2D NMR and mass spectroscopy methods.

Tóm tắt tiếng anh

Compounds containing thieno[3,2-b]thiophene generally exhibit good fluorescent properties and havean important role in the labeling of biological products. In our study, 04 derivatives containing thieno[3,2-b]thiophene structure were synthesized through cross-coupling reaction that directly activates the C-H bond using palladium catalyst. The different reaction conditions were investigated using two catalyst platforms Pd(OAc)2 and PdCl(C3H5)(dppb). Experimental results show that: ester A(1.5 equiv), A0 (1.0 equiv), PdCl(C3H5)(dppb), 3 mol%, KOAc (5 equiv) in DMAC solvent (1mL/0.02 mmol ester A), temperature 1300C and reaction time 24h is the best condition for the coupling reaction. The structures of the obtained derivatives were determined by 1D, 2D NMR and mass spectroscopy methods.

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