To improve the efficiency of the design and construction process, high-speed railway bridges (HSR bridges) are often modularized according to type, span, and cross-section properties. In addition to the architecture, geotechnical engineering, and construction technology requirements, the selected structural option also depends on the applied load and the limit state design according to the standards. This study analyzes the static behavior of prestressed reinforced concrete box girder bridges with a span of 20 m, 24 m and 32 m under the different live load models according to European, Japanese, and Chinese standards. For each structure, the support reaction, moment and vertical deflection at the middle, and the slope angle at the two ends of the beam are calculated with 9 different live load models. The study provides valuable conclusions and recommendations in selecting the live load model and limits states for the future design calculation standards of the HRS bridges in Vietnam.