This study is to evaluate the change of area in agricultural land uses in My Xuyen district, Soc Trang province through the satellite image data provided by Japan Aerospace Exploration Agency. The results showed a difference in the percentage of land use types changed in two areas of the district. For the freshwater region in the North of the district, there was little change of area in the rice crops and cash crops. These land use types were mainly converted for construction areas and other plantation trees. Meanwhile, there was high transformation in the saltwater and brackishwater ecology region, the area of rice-shrimp farming was reduced due to changing to the improved extensive and semi-intensive farming models. By the farmer interview method, these results showed that saline water intrusion, rainfall, costs of input materials, labor costs, consumption of materials in the production process, agricultural product prices, markets, lack of labors, and Covid-19 epidemic were important influences on production efficiency and farmers' decision to change land use