Since ancient times, river basins are often rich in land and water resources, so they have become key socio-economic regions of countries around the world. In these areas, the development of economic and social sectors has significantly changed and increased the demand for water throughout the region, putting pressure on sustainable planning and management of water resources. this limited natural resource. In addition, under the impact of climate change (CC), available water resources are expected to have abnormal changes. Therefore, the calculation and assessment of water use needs of water-using industries will help managers have an overview of the current situation and future water use requirements to serve as a basis for the water industry. Planning and management of water resources is a key factor for sustainable socio-economic development of the whole region. This study uses the detailed climate change scenario data of the global forecasting model MPI-ESM-MR, MPI-ESM-LR, HadGEM2-ES và NorESM1-M for up to 13 water use subdivisions in the Red River Delta (Red River Delta) of quantitative factors. Rain, temperature, combined with data, statistics on population, agriculture, industry, fisheries, livestock of provinces in the region to serve to calculate the demand of water-using industries in the period. status quo and forecast in 2030, with a vision to 2050. Calculation results show that the total water demand of the whole Red River Delta in 2020 is approximately 13.118 billion m3, in 2030 is approximately 14,523 billion m3, by 2050 it will be about 14,307 billion m3. Water demand in the future tends to decrease. However, compared with the period of 2020-2030, the water demand for the period of 2030-2050 for agriculture and aquaculture tends to decrease, while the demand for domestic use and industry increases.