Dong Van karst Plateau UNESCO Global Geopark (Ha Giang province), covering four districts of Quan Ba, Yen Minh, Dong Van, and Meo Vac on an area of 2,356 km2 , was established on September 9, 2009 and became a new UNESCO Global Geopark on October 3, 2010. Besides geological, geomorphological, stratigraphic, and paleontological features and values, the area is also characterized by interesting cave development and karst landscape. The karst and cave system are not only valuable in terms of landscape, tourism, and underground biodiversity, but the caves are also places to record information about paleontological conditions and tectonic development. In recent years, many studies have shown that the formation of karst topography and cave systems is mainly controlled by a complex combination of tectonic activities, geomorphological development, and climatic and hydrological processes. From the tectonic perspective, it is shown that 42% of the cave system is controlled by faults and neotectonic stress fields. Some previous studies have shown that the underground karst hydrology has a close relationship with the development of local topography and geology, which are controlled by a number of factors such as petrology, tectonics and stratigraphic boundaries. In this article, the structural-geological features and the relationship with the cave system in the Dong Van karst Plateau Global Geopark will be presented.