Catechin is a compound o f a number ofpolyphenols extracted from green tea leaves (Camellia sinensis L.) at id plays an important role in the biological activity’ of tea. Catechins include: (+) -Catechin, (-)-Epicatechin (EC), (-)-Epigallocatechin (EGC), (-)-Epicatechin Galate (ECG) and (-)-Epigallocatechin Gaỉate (EGCG). Previous studies have shown that Catechin has antimicrobial, antioxidant activity’ and is effective in the prevention and treatment o f mam’ types o f cancers. In this study, the microbial resistance o f tea leaf extract catechin (var TB14) was evaluated in the tea area o f Bao Loe, Lam Dong. The results showed that catechins were resistant to gram-positive strains such as Staphylococus aureus, Bacillus cereus, Rhodococus equi, and gram-negative strains such as Escherichia coli, Citrobacter freundii, Proteus mirabils, Salmonella enterica. In general, catechins are more gram-positive than gram-negative organisms.