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Nguyễn Thị Ngọc Linh, Thái Văn Bình, Đậu Đăng Thiện, Phan Thị Hồng Tuyết, Lưu Tiến Hưng, Nguyễn Hoa Du(1), Lê Thế Tâm

TỔNG HỢP HẠT NANO MnO BỌC POLY(VINYLPYRROLIDONE) VÀ ĐÁNH GIÁ ĐỘ TĂNG TƯƠNG PHẢN ẢNH TRONG CHỤP CỘNG HƯỞNG TỪ CHẨN ĐOÁN

SYNTHESIS OF POLY(VINYLPYRROLIDONE) CAPPED MnO NANOPARTICLES AND EVALUATION OF SIGNAL INTENSITY ON MAGNETIC RESONANCE IMAGING FOR DIAGNOSTIC

Tạp chí Phân tích Hóa, Lý và Sinh học

2024

2A

253

In this work, poly(vinylpyrrolidone) coated MnO nanoparticles (MnO@PVP NPs) were prepared by the polyol method using triethylene glycol (TEG) and poly(vinylpyrrolidone) (PVP) as solvents and surfactants. The materials' structure, morphology and characteristic properties were analyzed using XRD, TEM, FTIR and DLS measurements. MnO nanoparticles synthesized under optimized conditions have a spherical shape with an average size of 10.87 ± 1.19 nm, demonstrating good image contrast signal enhancement in magnetic resonance imaging (MRI) diagnostic techniques. Research results show that nano MnO@PVP NPshave a high value of longitudinal relaxivities r1 (5.28 mM-1s-1), reducing longitudinal relaxation times T1 and thus increasing MRI signal intensity. The research results show that PVP-coated MnO nanoparticles can be used as T1 positive contrast agents for diagnostic imaging applications shortly.

In this work, poly(vinylpyrrolidone) coated MnO nanoparticles (MnO@PVP NPs) were prepared by the polyol method using triethylene glycol (TEG) and poly(vinylpyrrolidone) (PVP) as solvents and surfactants. The materials' structure, morphology and characteristic properties were analyzed using XRD, TEM, FTIR and DLS measurements. MnO nanoparticles synthesized under optimized conditions have a spherical shape with an average size of 10.87 ± 1.19 nm, demonstrating good image contrast signal enhancement in magnetic resonance imaging (MRI) diagnostic techniques. Research results show that nano MnO@PVP NPshave a high value of longitudinal relaxivities r1 (5.28 mM-1s-1), reducing longitudinal relaxation times T1 and thus increasing MRI signal intensity. The research results show that PVP-coated MnO nanoparticles can be used as T1 positive contrast agents for diagnostic imaging applications shortly.

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