This study aims to evaluate water quality parameters in rivers and canals in Ke Sach district, Soc Trang province using principal component analysis (PCA) and cluster analysis (CA). Water quality data from 2017 to 2019 were collected at 26 locations with 10 parameters including pH, dissolved oxygen (DO), biochemical oxygen demand (BOD J, chemical oxygen demand (COD), total suspended solids (TSS), ammonium (N-NHf), chloride (Cl), nitrite (N-NO~), orthophosphate (P-POf) and coliform. Each water quality parameter was compared with national technical regulations on surface water quality (QCVN 08-MT: 2015/BTNMT). The findings showed that water quality in the study area was contaminated by organic matters (low DO, high COD), suspended solids and conforms, which is only suitable for irrigation and aquaculture purposes. PCA results presented that DO, COD, TSS, N-NHf, N-NO2, P-POf and coliform mainly affected the water quality due to domestic activities, agricultural production and hydrology. Therefore, these water parameters should be included in the water quality monitoring program in Ke Sach district, Soc Trang province. Cluster analysis (CA) revealed that water quality was classified into seven main groups due to difference in DO, TSS and coliform. Future study should investigate specific sources of water pollution in order to point out appropriate solutions to improve water quality in the study area.