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  • Công bố khoa học và công nghệ Việt Nam

76.29.51

Y học lâm sàng

Đặng Anh Tuấn, Nguyễn Văn Thắng(1), Cao Vũ Hùng, Lê Nam Thắng, Hoàng Tùng Lâm, Hoàng Ngọc Thạch

Nhân chín thường hợp động kinh cục bộ kháng thuốc ở trẻ em được điều trị kết hợp nội và ngoại khoa tại bệnh viện Nhi Trung ương

Drug-resistant localization-related epilepsies in children at National Hospital of Pediatrics: A case series report

Y học Việt Nam

2012

DB

281-288

1859-1868

Drug-resistant localization-related epilepsies are a heterogeneous group of diseases characterized by partial-onset seizures, nonresponsiveness to pure medical treatment and the presence of an underlying epileptogenic lesion. Objective: To describe clinical manifestations and some chacteristics of the epileptogenic lesion in nine children suffering from drug-resistant localization-related epilepsies who have received both medical and surgical treatment. To remark the initial outcome of the abovementioned treatment. Result: Nine children with drug-resistant localization-related epilepsies have been treated medically and surgically at National Hospital of Pediatrics over a two-year period (2010-2012). Anatomically, temporal lobe involvement accounts for 55.5 percent of cases (5/9) and frontal lobe or multi-lobar involvements account for the remaining 44.4 percent (4/9). Histopathologically, lowgrade tumors: 33 percent, FCD: 33 percent, hippocampal sclerosis: 11 percent, acquired cerebral hemiatrophy: 11 percent and unremarkable: 11 percent. The initial success rate stands around 72 percent. Conclusion: Drug-resistant localization-related epilepsies in children could be cured radically by surgery combined with medical treatment.

TTKHCNQG, CVv46