Droughts and water shortages in the dry season of the Mekong River Delta are becoming more and more serious due to their frequency of occurrence and causing more serious socio–economic losses. Because surface water characteristics of the Mekong Delta depend largely on water from outside the territory, it is necessary to have studies to analyze the components that make up the dry season flow into the Mekong Delta. This study will evaluate the role of Tonle Sap Lake on dry season flow into the Mekong Delta by statistical methods and use MIKE11HD model. Base on the result, at end of October, the flow from Tonle Sap Lake will begin to flow downstream in about 180 days with a total volume of water about 40 billion from November to April. On average, from November to April, Tonle Sap Lake contributes about 36% of the total flow volume to the downstream. In December, the lake largely contributes the flow to the downstream, which is even higher than flow contribution from the mainstream. By the end of the dry season, the lake only contributes about 15% to 16% of the total flow downstream in Viet Nam. With contributions from Tonle Sap Lake, the discharge on the Tien and Hau rivers in typical drought years increases from 15% to 30%, contributing to the prevention of salinity intrusion into the Mekong Delta.