Lọc theo danh mục
  • Năm xuất bản
    Xem thêm
  • Lĩnh vực
liên kết website
Lượt truy cập
 Lượt truy cập :  20,370,433
  • Công bố khoa học và công nghệ Việt Nam

76.31.31

Dược học

Phùng Thanh Hương(1), Nguyễn Thị Đông

Tác dụng của phân đoạn chiết thân ý dĩ trên chuột tăng glucose huyết thực nghiệm bởi streptozocin

Hypoglycemic activity of chloroform fractions from stem extracts of Coix lachryma-jobi on streptozocin induced hyperglycemia in mice

Dược học

2014

453

20-25

0866-7861

As the ethanol stem extracts of Coix lachryma-jobi exhibited hypoglycemic effects in mice, of which the chloroform fractions were the most potent, in this study, the chloroform fractions were tested on streptozocin (STZ) injected mice. The fractions exerted hypoglycemic effects same as the reference drug metformin on hyperglycemic mice induced by both doses of STZ. Meanwhile, the standard drug gliclazide showed hypoglycemic effects only on those mice injected the lower dose of STZ. The hypoglycemic mechanism of Coix lachryma-jobi stems was revealed in part by its effects on insulinemia and hepatic G6Pase activity. In addition, the hypoglycemic effects of the tested fractions were due to gluconeogenetic inhibition, and maybe, improvement of insulin resistance, as well.

TTKHCNQG, CVv13