Nghiên cứu xác định độc tính cấp tính và bán trường diễn của dung dịch Ceri Nitrat và gel Ceri Nitrat

Chỉ số đề mục

76.31.29

Lĩnh vực nghiên cứu

Dược học

Dạng tài liệu

Tác giả

Nguyễn Ngọc Tuấn, Nguyễn Văn Thịnh, Lương Quang Anh, Thanh Son Tran⁽¹⁾

Nhan đề

Nghiên cứu xác định độc tính cấp tính và bán trường diễn của dung dịch Ceri Nitrat và gel Ceri Nitrat

Nhan đề tiếng anh

Investigating acute and sub-acute toxicity of the cerium nitrate solution and cerium nitrate gel

Nguồn trích

Y học thảm họa và bỏng

Năm xuất bản

2014

Số

4

Trang

25-34

ISSN

1859-3461

Từ khóa

Ceri Natri, Độc tính cấp tính, Độc tính bán trường diễn, Nghiên cứu, Chuột cống trắng

Từ khóa tiếng anh

Tóm tắt

Tóm tắt tiếng anh

Cerium nitrate (CN) is a nitrate of the rare earth metal which has been widely used for local treatment of severe bum injuries. The purpose of present study is to evaluate acute toxicity of the CN 0,04 M solution and sub-acute toxicity of gel CN 0,05 M prepared by the NIB in Wistar albino rats. Both acute and sub-acute studies were done according to the Organization for Economic Cooperation and Development (OECD). In the acute toxicity study, solution of CN were administered to six rats at dose of 2000mg/kg, the rats were observed for 24 hours. No toxic signs/mortality was observed. In the sub-acute study, solution CN 0,04 M (n=10) and gel CN 0,05 M (n=10) were administered once daily for 28 days to rats at dose of 1000mg/kg, orally. No toxic signs/mortality was observed. There were no significant changes (p 0.05) in the body weights, haemato-biochemical parameters. No gross/histopathological lesions were observed in liver, spleen and renals of the rats.

Kí hiệu kho

TTKHCNQG, CVv 156

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Tài liệu tham khảo

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