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  • Công bố khoa học và công nghệ Việt Nam

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Y học lâm sàng

Lê Văn Quảng, Nguyễn Khánh Toàn, Phan Bách Thắng(1)

Độc tính của hóa chất Oxaliplatin và Xeloda trong điều trị ung thư dạ dày giai đoạn muộn

The toxicity profile of oxauplatin and xeloda in the treatment of advanced stage gastric cancer

Y học Việt Nam

2014

2

113-117

1859-1868

Objectlve:To evaluate the toxicities of palliative chemotherapy combination XELOX in the treatment of advanced stage gastric cancer. Patients and methods: 52 inoperable advanced stage gastric cancer patients treated by palliative chemotherapy combination XELOX from 01/2011 to 06/2013 in K hospital. The prospective descriptive study. Results: The most often seen toxicity was anemia, 69,2 percent, mild to moderate grades. Neutropenia accounted for 67,3 percent, in which grade 3 accounted for 11,5 percent, none was neutropenic fever. Nephrotocixity 11,5 percent and all was mild grade. Hepatotoxicity was grad 1-2 transaminase elevation, 41,2 percent. The non hematoxicities predominantly were mild to moderate grade vomiting, oral mucositis and diarrhea. Hand-foot syndrome 42,2 percent in which 1,9 percent severe grade leading to dose reduce. There was correlation between neutropenia and the age older than 60 or full dose treatment. Conclusion: The combination XELOX was quite safe with seldomly seen severe grade toxicity. So that it could be used for elderly advanced gastric cancer patients.

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