Background: Get fetal specimens by aspiration of amniotic fluid is a method widely used today in the prenatal diagnosis center in the world because of the easy, effective, and less complications. This method is also carried out at the central maternity hospital after a prenatal diagnosis center and proved to be very effective. Study objectives: Describe the rate of fetal chromosomal abnormalities in amniocentesis and find out the relationship between the indications for amniocentesis with other fetal chromosomal abnormalities. Subjects and Methods: crosssectional descriptive study on 2686 women who had amniocentesis fetal chromosome map at Prenatal Diagnostic Center-Central Obstetrics Hospital for five years (2006-2011). Results: The rate of fetal chromosomal abnormalities was 9.1 percent, in which HC Down to 4.3 percent. Ultrasound morphology with the highest positive prognostic value of the specified amniocentesis (26.4 percent), maternal age 2:35 (9.3 percent), a positive screening test (8.8 percent), a history of birth defects (8.3 percent). Conclusion: The method aspirate amniotic fluid fetal chromosome analysis is recommended to apply in prenatal diagnosis to detect fetal chromosomal abnormalities, and coordinate the specified diagnostic amniocentesis increases the efficiency.
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