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Dương Thúc Huy(2) , Nguyễn Hữu Hùng , Nguyễn Thị Ánh Tuyết , Bùi Xuân Hào(1)

Thành phần hóa học rễ cây chùm ruột mọc ở tỉnh Bình Thuận

Triterpenoids f-rom Phyllanthus acidus (L.) Skeels

Tạp chí Phát triển Khoa học & Công nghệ: Chuyên san Khoa học Tự nhiên

2018

2

The genus Phyllanthus (Phyllanthaceae) includes more than 900 plant species found in tropical and subtropical regions. Many of these species are widely used in folk medicine. The leaves, roots, and stem bark of Phyllanthus acidus (L.) Skeels have been used in Vietnamese folk medicine as an antibacterial, antiviral, analgesic, anti-inflammatory, neuroprotective, hepatoprotective, antifibrotic. F-rom the ethanol extract of the roots of Phyllanthus acidus (L.) Skeels growing in Binh Thuan province, six compounds phyllanthol (1), glochidone (2), lupeol (3), glochidonol (4), -lupene (5), and spruceanol (6) were isolated. Their structures were established by extensive spectroscopic analysis as well as comparison with NMR data in the literatures. This is the first time that compounds 4-6 were found in Phyllanthus acidus (L.) Skeels. Keywords—Phyllanthus acidus (L.) Skeels, lupane, phyllanthol, triterpene

The genus Phyllanthus (Phyllanthaceae) includes more than 900 plant species found in tropical and subtropical regions. Many of these species are widely used in folk medicine. The leaves, roots, and stem bark of Phyllanthus acidus (L.) Skeels have been used in Vietnamese folk medicine as an antibacterial, antiviral, analgesic, anti-inflammatory, neuroprotective, hepatoprotective, antifibrotic. F-rom the ethanol extract of the roots of Phyllanthus acidus (L.) Skeels growing in Binh Thuan province, six compounds phyllanthol (1), glochidone (2), lupeol (3), glochidonol (4), -lupene (5), and spruceanol (6) were isolated. Their structures were established by extensive spectroscopic analysis as well as comparison with NMR data in the literatures. This is the first time that compounds 4-6 were found in Phyllanthus acidus (L.) Skeels. Keywords—Phyllanthus acidus (L.) Skeels, lupane, phyllanthol, triterpene

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