The article has developed scenarios in in emergency cases for Nuoc Trong Lake and assessed the effects of simulated flooding in cases on the downstream of Tra Khuc River (inundated area, the number of affected households, the number of affected people). The article has used MIKE FLOOD model to simulate flooding downstream of a hydroelectric reservoir on Tra Khuc river basin after the model was calibrated and validated with 3 massive floods in November 2013, November 2017, November 2020 and the survey results flood traces and cross–sections were conducted during the flood season in 2020. The model has used well–calibrated parameters to simulate and evaluate inundation in the basin under the impact of Nuoc Trong reservoirs according to the designed flood discharge scenario and dam break scenario. The results show that the largest flooded area in Tra Khuc river basin corresponding to the frequency of design flood discharge and bursting of the spillway of the dam (Scenario 6) is about 25,885 ha and concentrates in some communes such as Tinh Ha, Tinh Phong, Nghia Ha, Nghia Lam. In the scenario of flood discharge exceeding the design 0.02% (Scenario 5 ), the largest flooded area on Tra Khuc river basin is about 25,606 ha. In the design flood discharge scenario of 0.5% (Scenario 1) is about 21,556 ha and flood discharge according to flood frequency 10% (Scenario 4) is about 11,619 ha. In the calculated scenarios, the most affected households are about 75,183 households and the number of affected people is about 28,6568 people.