Lọc theo danh mục
  • Năm xuất bản
    Xem thêm
  • Lĩnh vực
liên kết website
Lượt truy cập
 Lượt truy cập :  20,018,181
  • Công bố khoa học và công nghệ Việt Nam

Khoa học y, dược

BB

Đặng Thái Hoàng, , Nguyễn Văn Giang, Nguyễn Văn Giang, Nguyễn Văn An, Nguyễn Thu Huyền, Phạm Hải Long, Nguyễn Thị Sơn, Đỗ Huy Hoàng(1)

TỔNG HỢP VÀ HOẠT TÍNH ỨC CHẾ ENZYME Α-GLUCOSIDASE CỦA DẪN XUẤT DICLOROPHENYLINDOL-2-ON

SYNTHESIS AND Α-GLUCOSIDASE INHIBITION OF DICLOROPHENYLINDOL-2-ONE DERIVATIVES

Tạp chí Phân tích Hóa, Lý và Sinh học

2022

4

206

Oxindole (indol-2-one) is a crucial scaffold in medicinal chemistry for very common commercial drugs. In our work, two oxindole derivatives have been synthesized, and confirmed by 1H & 13C-NMR, IR andMS data. Compound 2 and 3 showed potent inhibitory activity against α-glucosidase with IC50 values of 57.5 and 348.7 μM, respectively. Molecular docking has been studied for the binding interactions of these compounds with the active sites of the enzyme. Moreover, parameters drug-likeness and ADME properties were calculated

Oxindole (indol-2-one) is a crucial scaffold in medicinal chemistry for very common commercial drugs. In our work, two oxindole derivatives have been synthesized, and confirmed by 1H & 13C-NMR, IR andMS data. Compound 2 and 3 showed potent inhibitory activity against α-glucosidase with IC50 values of 57.5 and 348.7 μM, respectively. Molecular docking has been studied for the binding interactions of these compounds with the active sites of the enzyme. Moreover, parameters drug-likeness and ADME properties were calculated