Nowadays, with the support of Technology 4.0, construction enterprises have had so many inovation and creativity in operation. However, besides the potential benefits, there are many challenges which make the level of digitization and automation of enterprises at a low level. This research aims to determine the impacts of Technology 4.0 to construction enterprises in Ho Chi Minh City, through conducting a survey with individuals and experts in this field. There are 37 impacts given in the questionnaire and data collected 117 valid responses. After analyzing, the impacts are divided into 2 main groups: Benefits (4 subgroups) and Challenges (6 subgroups). Research results have identified the most significant impacts of Technology 4.0 that brings to enterprises in the Construction Industry. Then, making appropriate solutions help construction enterprises approach and apply science and technology, promote the development of enterprises through the benefits of Technology 4.0.