This research aims to analyze the impact of saline intrusion on land use/land cover (LULC) and assess the vulnerability of agricultural land in Tien Giang province in 2020. The methodology applied an Object-Based Image Analysis (OBIA) on Landsat 8 images and an unsupervised classification on MODIS images to create land use/land cover and rice crops maps in Tien Giang province in 2020. The assessment is evaluated based on 2 parameters, including overall accuracy (T) at 85.6% and Kappa coefficient at 0.79. The LULC distribution consists of seven groups: triple-rice crops, double-rice crops, single rice crop and aquaculture combination, perennial land, aquaculture, construction land, and rivers. The highest total area of rice cultivation accounts for 47.5%, and the lowest is aquaculture with 4.7%. The study estimated vulnerability based on three main components, including exposure (E), susceptibility (S), and adaptive capability (AC). The vulnerability impacts LULC in the salinity intrusion areas with the highest on triple-rice crops and perennial lands; and the lowest on aquaculture in Tien Giang province