Vietnam is a major coffee exporter in the world with an estimated annual output of more than one million tons. From the production of green coffee, a large amount of defective green coffee beans arediscarded. The collection of these defective green coffee beans for medicinal purposes has made full use of natural resources, bringing great value in both economy and environment. The study was carried out with the following methods: Recovering of green coffee extract by impregnating in ethanol; Testing for antimicrobial activity; Syntheticing nano silver - green coffee AgNPs-GCB. The results showed that the high amount of extract obtained from discarded coffee beans reached 28.5-29.1%. Green coffee extract (GCB) has chlorogenic acid (CGA) reaching 6.7%, caffeine 2.7% and could be used in pharmaceutical chemicals and cosmetics. Green coffee extract, in addition to the known traditional medicinal effects, is also a biologically active substance, reducing sugar, a stable emulsifying support system in the production of nano-biomaterials to create nano-AgNPs-GCB for creating added value from waste for coffee production