Brugada syndrome is a condition associated with cardiac sodium channel abnormalities in a structurally normal of heart. Diagnosis of the disease is based on features on electrocardiogram plus clinical manifestations and/or genetic examination. Patients with Brugada syndrome can suddenly die from ventricular arrhythmias without predicted symptom, so if surgery is required, the risk is very high. Anesthesiologists need to understand the pathogenesis of the disease, the predisposing factors for the occurrence of arrhythmias, and the drugs that can trigger the arrhythmia. Thereby, it warrants to select the appropriate method of anesthesia and appropriate anesthetics to ensure maximum safety for this patient. Based on a review of a series of case reports plus literature review, the solution for this type of patients was to have an external defibrillator ready, control risk factors, maintain anesthesia with inhalational anesthetics, and not to administer infused propofol continuously.
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