The port dredging activity is the process of using dredging equipment to remove mud and sand within the port to create a deeper port area, aiming to enhance vessel reception capability, bolster cargo transportation capacity, and foster commercial activities at the port. This process has stirred up sediment particles on the seabed, spreading to surrounding areas and affecting the marine habitats of organisms such as coral reefs, seagrass beds, and other marine species. In this study, the MIKE 3 model was applied to simulate the hydrodynamic regime and turbidity dispersion resulting from dredging activities for sand extraction in the Nghi Son port area, Thanh Hoa province under seasonal wind conditions. The research results indicate that the nearshore flow velocity in the port area during the southwest monsoon period is higher than during the Northeast monsoon period. The turbidity dispersion process from sand dredging activities significantly depends on the flow regime within the port. After 4 weeks of dredging operations, the sediment concentration inside the port reaches 1,2 kg/m3, while outside the port, it decreases to approximately 0,15 kg/m3. After 6 weeks of dredging within the port, the sediment turbidity tends to spread towards the outside of the port, with a sediment concentration of 0,015 kg/m3, influenced by tidal currents. After 8 weeks of dredging, the sediment concentration tends to move towards the coastal embankment outside the port, reaching around 0.08 kg/m3. After 10 weeks of dredging, the turbidity plume disperses along the southern coastline of Nghi Son port, with sediment concentrations reaching approximately 0,004 kg/m3.