To compare the pain relief effec after knee arthroscopy between the saphenous nerve block at the adductor canal combined with interspace between the popliteal artery and capsule of the knee (IPACK) and the adductor canal block alone. Methods: Clinical intervention study, randomized controlled trial; 60 patients undergoing arthroscopic knee surgery were divided into 2 group by random numbers. OCK group: Patients had postoperative pain relief by adductor blockade alone; IPACK group: patients were relieved by adductor canal block in combination with IPACK. Follow-up patients within 48 hours after surgery, data are coded and processed according to statistical methods. Results: The total dose of morphine used in 12-24h and 48h in IPACK group was much lower than that of the simple adductor block group. The 48-hour mean morphine dose was 21.27 ± 5.56 mg versus 41.33 ± 5.84 mg. The time required for the first morphine dose of the intervention group was also much longer than that of the control group 7.67 ± 1.01 h (6h shortest and 8h longest) compared with 9.55 ± 0.80 01h (shortest was 8h and longest was 11h).VAS score of IPACK group at the time after the blockade for 10 minutes and in the first 18 hours after surgery, both at rest and during exercise, were statistically significantly lower than in the simple adductor block group. Conclusion: The saphenous nerve block at the adductor canal combined with interspace between the popliteal artery and capsule of the knee block under ultrasound guidance is an effective pain relief method for knee arthroscopy and is better than the simple adductor block.