This study aims to measure the factors affecting the online shopping intention of consumers in Ho Chi Minh City. The study’s research sample included 200 consumers aged from 18 to 55 years old and the study's data was collected via an online survey, then analyzed quantitatively by using SPSS Statistics 20.0. The study finds out that there are four factors affecting the intention of shopping online of consumers in Ho Chi Minh City. These factors are the perceived convenience, ease of use, trust, and social influence. In particular, the ease of use has the greatest impact on the intention of consumer to do their shopping on the Internet. Based on these empirical results, some managerial implications are proposed to help businesses improve their online retail services, thereby increasing the intention of consumers to do their shopping online in Ho Chi Minh City in particular and in Vietnam in general.