Over the past decades, great powers, typically the United States, have consistently pursued strategies to enhance their influence and protect their national interests in the Indo-Pacific, a crucial geopolitical and geostrategic region. In late 2017, as US President, Donald Trump announced the Indo-Pacific strategy which centered on containing the rise of China and maintaining America’s No.1 status. In January 2021, Joe Biden took over from Donald Trump after his four-year tenure and followed the same strategy. The paper aims to explore differences between the two presidents’ strategic approaches to the Indo-Pacific to explicate the new adjustments in the US foreign policy to the region.