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Y học lâm sàng

Nguyễn Như Nghĩa, Hà Hoàng Kiệm, Vũ Đình Hùng, Nguyễn Thị Ngoan(1)

Nghiên cứu ảnh hưởng của lọc máu trên nồng độ Peptid lợi tiểu thải Natri typ B ở bệnh nhân suy thận mạn tính lọc máu chu kỳ

Influences of hemodialysis on plasma levels of the B-type natriuretic peptide in chronic renal failure patients

Y Dược lâm sàng 108

2014

3

38-42

1859-2872

Objective: To determine the influence of hemodialysis on plasma levels of the B-type natriuretic peptide in chronic renal failure patients. Subjects and methods: The prospective, cross-sectional descriptive study consisted of 61 patients who aged more than 18 years old and have been receiving dialysis for at least 3 months at Can Tho Central General Hospital and Can Tho General Hospital. Results: The medians of pre-dialysis BNP, post- dialysis BNP, and the change in BNP were 1046 [28.2- 9420] pg/mL, 1131 [23- 9870] pg/mL, and 11 [-2264 - 1048] pg/mL, respectively. Plasma level of brain natriuretic peptide did not change significantly after hemodialysis. BNP was found to increase in 39 patients (63:9 percent) and decrease in 22 (36.1 percent). BNPRR significantly associated with KtN (r = -0.34, p= 0.006), URR (r = -0.41, p=0.001). However, there is no relationship between BNPRR and the time on dialysis, change in weight, and ultrafiltration volume (p 0.05). Conclusion: Plasma level of B- type natriuretic peptide did not decrease significantly after hemodialysis in ESRD patients.

TTKHCNQG, CVv 337