Describe symptoms, colonoscopy results, pathology (if available) of the group of patients with or without alarm features according to ROME IV criteria and identify some risk factors in the group of patients with colorectal advanced neoplasms. Subjects and methods: Cross – sectional study, recording symptoms and colonoscopy results of patients 18 years and older underwent colonoscopy at with IBS-like symptoms. Results: We collected 265 cases completed colorectal endoscopy: 163 patients (61,5%) have ROME IV IBS-like symptoms; 41,72% of them had normal colonoscopy result; 95 cases had lesion, include: 33,74% colitis, 9,82% adenoma and 3,68% colorectal cancer. In the group of patients not having any alarm features, the rate of anatomic abnormalities was low, and no colorectal advanced neoplasms was recorded. The predictive models for colorectal advanced neoplasms are: (1) age, rectal bleeding, weight loss (OR: 1,07, 10,47 and 7,74); (2) rectal bleeding, weight loss and APCS score (OR: 7,47, 1,41 and 2). Conclusion: In the group of patients with no alarm features, the majority has normal colonoscopy results. Rate of colorectal advanced neoplasms is low in IBS-like symptoms; but all of them have alarm features and high APCS score. Therefore, before diagnosing IBS, we suggest that attention should be paid to eliminate these risk factors.