To evaluate the primary outcomes of Norwood-Yasui operation for patients diagnosed with interrupted aortic arch-ventricular septal defect and severe left ventricular outflow tract obstruction at Heart Center, Vietnam National Children Hospital. Methods: From May 2012 to February 2022, 8 patients who underwent Norwood operation or Yasui procedure for left ventricular outflow tract bypass were retrospectively reviewed. Results: The median age and median weight of patients at the primary repair were 30.5 days (IQR, 21.5-37.5 days) and 3.15 kg (IQR, 2.7-3.8 kg). The mean time for bypass, aortic cross-clamp time, and selective regional cerebral perfusion time were 146.6 25.1 minutes, 99.4 21.2 minutes, and 47.4 8.9 minutes, respectively. The median time for ventilation and hospital stays were 171 hours (IQR, 141.5 – 238 hours) and 29.5 days (IQR, 19.5 – 34.5 days). There were two patients died in hospital after Norwood operation. One patient underwent primary Yasui operation, and there were 4 patients who underwent biventricular repair as the second operation at the last follow-up (2 patients had Ross-Konno operation, 1 patient have Yasui procedure, and 1 patient underwent ventricular septal defect closure and resection of the conus septum), 1 patient who have Gleen operation and now waiting for biventricular repair. Conclusions: Staged repair for patients with severe left ventricular outflow tract obstruction-interrupted aortic arch-ventricular septal defect is reasonable and feasible for this complex congenital heart defect. Close follow-up in this specific group is essential to maintain survival and good outcomes.