Marine waste pollution has been a pressing issue in Vietnam's coastal areas and globally. In Da Nang Bay, a continuous influx of waste from the Han River causes environmental pollution and negatively impacts urban aesthetics. Therefore, studying the propagation and distribution of floating waste in Da Nang Bay, specifically waste originating from the Han River, is essential. The authors utilized the MIKE21FM numerical model to simulate the propagation and distribution of floating waste in Da Nang Bay. The hydrodynamic and spectral wave modules were applied to calculate wave and current propagation within the computational domain, and the particle tracking module was used to simulate the propagation and distribution of floating waste. A nested grid method was employed to assess the influence of large-scale hydrodynamic processes in the East Vietnam Sea on waste propagation and distribution in the Bay. The research results indicate that a combination of hydrodynamic factors influences the propagation and distribution of floating waste in Da Nang Bay. During the Northeast monsoon season, under the influence of river flows, ocean currents, waves, and tides, the waste tends to drift northwestward within the Bay and accumulates near the coast. Conversely, during the Southwest monsoon season, waste distribution in Da Nang Bay shifts toward the southwest and disperses further offshore. To devise effective waste collection strategies, the authors propose developing a real-time simulation and forecasting system for waste propagation and distribution in Da Nang Bay. This system would utilize meteorological and hydrological data from local stations or national and international meteorological organizations.