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  • Công bố khoa học và công nghệ Việt Nam

76.03.31

Công nghệ sinh học trong y học

Nguyễn Thị Kim Phương, Lê Thị Thanh, Ngô Hương Giang, Nguyễn Vũ Sơn(1), Phạm Thị Thu Hằng, Hoàng Vũ Mai Phương, Trần Hải Anh

Lựa chọn chủng vi rút dự tuyển cho phát triển vắc xin cúm A/H1N1pdm09 tại Việt Nam

Influenza A/H1N1 pdm09 vaccine candidate strains selection to vaccine development in Viet Nam

Y Dược lâm sàng 108

2014

3

118-125

1859-2872

Objectives: To evaluate, select influenza vaccine candidate strain to develop the influenza A/H1N1 pdm in Vietnam. Subjects and methods: MDCK viruses propagation, heamagtutinine inhibition assay, Sanger sequence gene on 85 viruses Vietnam A/H1N1 pdm09 strains during 2009-2013. Results: 46/85 A/H1N1 pdm09 strains had HA titer 128 which were sequenced HA gene. Their HA genes referred to 4 groups (l,5, 6 and 7). The subgroup 6C had high number of Vietnamese strains (23/76) in the year of 2013. Four strains had HI titer 1280 with reference antigen were collected, of those, two viruses A/VN/36947/2013 and A/VN/13284/2013 posed the homology with circulating virus to ensure high protect efficacy of vaccine development in Vietnam. Conclusion: The selection of influenza candidate vaccine strains is necessary in Vietnam due to the year round influenza circulation. Two A/H1N1 pdm09 strains A/VN/36947/2013 and A/VN/13284/2013 were selected for producing influenza vaccine in the future in Vietnam.

TTKHCNQG, CVv 337