Đột biến gen HBx ở bệnh nhân ung thư gan nhiễm virus viêm gan B

Chỉ số đề mục

34.23; 76.29.49

Lĩnh vực nghiên cứu

10609 - Di truyền học; 302 - Y học lâm sàng

Dạng tài liệu

Tác giả

Trần Hà Hiếu, Lê Hữu Song⁽¹⁾

Nhan đề

Đột biến gen HBx ở bệnh nhân ung thư gan nhiễm virus viêm gan B

Nhan đề tiếng anh

HBx gene mutation in hepatocellular carcinoma patients infected with hepatitis B virus

Nguồn trích

Tạp chí Nghiên cứu Y học

Năm xuất bản

2011

Số

5

Trang

1-6

ISSN

0868-202X

Từ khóa

Đột biến gen HBx, Bệnh nhân ung thư gan, Virus viêm gan B

Từ khóa tiếng anh

Tóm tắt

Tóm tắt tiếng anh

HBx gene mutation is associated with the progression of hepatocellular carcinoma (HCC). The study was conducted to investigate the HBx gene mutation in HCC patient infected with HBV and its relationship with laboratory parameters. Five point mutation were identified in HBx gene such as A1762T, G1764A, C1653T, T1753C/G va C1766T. ,Among these, A1762T, G1764A and C1653T were found more frequent with 66 percent, 83 percent and 81percent, respectively. A1762T and G1764A was more frequent in poor differentiated group compared to well differentiated group (100 percent vs 67 percent, P 0.05). HBx gene mutation is no associated with liver function as well as HBeAg status. In conclusion, HBx gene mutation rate is relative high in HCC patient infected with HBV and A1762T/G1764A mutation are associated with differentiated grade of liver cell.

Kí hiệu kho

TTKHCNQG, CVv251

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