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  • Công bố khoa học và công nghệ Việt Nam

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Y học lâm sàng

Nguyễn Hữu Trường, Tran Viet Hung(1)

Tương quan giữa nồng độ kháng thể kháng chuỗi kép DNA với mức độ hoạt động của bệnh lupus ban đỏ hệ thống

Correlation between levels of anti-dsDNA antibodies and disease activity in systemic lupus erythematosus

Y học thực hành

2014

10

2-5

1859-1663

Objective: To determine thft correlation of anti-dsDNA level and clinical activity of systemic lupus erythematosus disease and lupus nephritis. Materials and methods: A cross-sectional study was conducted to 160 SLE patients. The patients were measured levels of anti-dsDNA by ELISA method, C3, C4. Clinical activity of SLE disease and lupus nephritis was evaluated by SELANA-SLEDAI and SLICC score, respectively. Results: In groups of SLE patients with highly active, intermediately active and inactive disease, the median concentration of anti-dsDNA (lU/ml) were 67.92 + or - 122.9; 139.33 + or - 146.87 and 269.76 + or - 231.3, respectively. SLEDAI score had a stronger correlation with the level of anti-dsDNA (r = 0.61) than C3 (r = -0.48), C4 (r = -0.47) and SLICC score (r = 0.296). Levels of anti-dsDNA in groups of patient with lupus nephritis or renal flares were higher than in group of patients with non-renal lupus or inactive nephritis, respectively. Conclusion: The level of anti-dsDNA in SLE patients is highly correlative with the clinical activity of SLE and lupus nephritis.

TTKHCNQG, CVv 57