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  • Công bố khoa học và công nghệ Việt Nam

76.29.29

Y học lâm sàng

Trần Thị Kiều My, Đỗ Trung Phấn, Nguyễn Anh Trí(1), Bạch Quốc Khánh

Hội chứng Retinoic Acid trong điều trị Lơxêmi cấp tiền tủy bào bằng Atra phối hợp hóa chất

Retinoic acid syndrome in patients following the treatment of acute promyelocytic leukemia with all-trans retinoic acid plus chemotherapy

Tạp chí Y học Việt Nam

2012

SDB

59-63

1859-1868

Objective: study on 69 newly diagnosed APL treated with ATRA plus Daunorubicin from 2007 to 2010. Method: 69 newly diagnosed APL patients were admitted to NIHBT during 20072010 period. Regimes used for treatment include ATRA combined Daunorubicin for induction. Result: The incidence of RAS in this study was 31.9 percent. The RAS-related mortality rate was 4.5 percent (1 out of 22 patients). The significant increase of RAS in patients with WBC count greater than 10-109/1 (57.7 percent to 16.3 percent, p0.05), and male (83.3 percent to 46.9 percent, p0,05). Conclusion: The incidence of RAS in this study was 31.9 percent. The initial WBC count greater than 10-109/1, especially in male correlated with an increased risk of developing RAS.

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