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  • Công bố khoa học và công nghệ Việt Nam

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Dược học

Bùi Khắc Cường(1), Hồ Anh Sơn, Nguyễn Văn Thư, Nguyễn Văn Long, Nguyễn Lĩnh Tuấn

Tác dụng ức chế và tăng sinh dòng tế bào ung thư đại tràng của tỏi Lý Sơn

Anti-proliferative effect of Ly Son garlic on human colon cancer cells

Y học Việt Nam

2013

1

19-23

1859-1868

Previous studies in recent years suggest that garlic has anti-proliferative effects against various types of cancer. In this study, the authors investigated anti-cancer activities of Ly Son's garlic extract on HT-29 human colon cancer cells by using trypan blue and MTT assays. Results showed that Ly Son's garlic extract solution was significant inhibition of HT-29 cells replication in comparison to control group. At the time point of 24, 48, and 72 hours after treated with 5 mg/ml and 10 mg/ml of Ly Son's garlic extracts have been shown significant inhibition the HT-29 cell proliferation (p0.01). Additionally, at concentration of 10 mg/ml, the Ly Son's garlic extract was significant inhibition of the HT-29 cells replication in comparison to the cells treated with 0,05 ug/ml of vincristine at 48 and 72 hours following up (p0.05). This finding indicates anti-replication of Ly Son's garlic on HT-29 human colon cancer cells.

TTKHCNQG, CVv 46