The study is aimed to assess the nutrient contents of the natural water environment in striped catfish farming areas, An Giang province. Findings of the study would provide warnings and measures for appropriate water quality management toward the sustainabledevelopment of striped catfish farming and protection of water resources in the area. Samples were collected at 3 sites in the Hau river and 3 sites in water supply canals in the intensive striped catfish farming areas. The samples were collected 4 times a year including March, June, September, and December, 2019. The results showed that nutrient contents at the water supply canals were higher than those on the Hau river. During the dry season, the nutrient contents tended to be higher than in the rainy season, especially in water supply canals. The water quality of the natural water surrounding the intensive striped catfish farming areas was directly affected by fish ponds. Phosphate, total nitrogen and total phosphorus concentrations were high at the sites sampling. It is, therefore, necessary to monitor and apply appropriate treatments when using water for different purposes.