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  • Công bố khoa học và công nghệ Việt Nam

76.29.29

Y học lâm sàng

Trần Minh Điển(1), Đặng Văn Thức, Phạm Hồng Sơn, Trịnh Xuân Long, Đặng ánh Dương

Hiệu quả của Iloprost đường tĩnh mạch trong điều trị tăng áp lực động mạch phổi sau phẫu thuật tim mở

The effects of intravenous iloprost in the treatment of pulmonary hypertension in the patients after open heart surgery at National hospital of pediatrics

Tạp chí Nghiên cứu Y học

2012

3A

80-86

0868-202X

The objective of this study was to assess the effects of intravenous iIoprost in the treatment of pulmonary hypertension in the patients after open-heart surgery at National Hospital of Pediatrics. The results showed that systolic pulmonary artery pressure decreased after iIoprost treatment: from 47.22 + or - 9.76mmHg to 40.38 + or - 9.61 mmHg (p 0.001) after 4 hours of time and 35.25 + or - 10.14mmHg (p 0.001) after 24 hours, which had statistical significance. Blood pressure was stable before and after iIoprost therapy. The patient respiratory improved with FiO2 gradually decreasing from 83 + or - 22.1 percent to 52.97 + or - 21.83 percent with P 0.001, PaO2/FiO2 increased from 189.65 + or - 114.05 to 286.54 + or - 199.92 with P 0.001. Diuresis increased from 2.36 + or - 1.07 ml/kg/h to 3.36 + or - 1.3 ml/kg/h and blood lactate decreased from 1,52 + or - 0.76 to 1.00 + or - 0.53 (p 0.001). In conclusion, Intravenous iIoprost combined with routine measures effectively in the treatment of perioperative pulmonary hypertension.

TTKHCNQG, CVv251