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  • Công bố khoa học và công nghệ Việt Nam

76.03

Công nghệ sinh học trong y học

Trần Huy Hoàng, Heiman Wertheim, Trần Như Dương(1), Nguyễn Bình Minh, Trần Vân Phương, Trịnh Hồng Sơn, Đặng Đức Anh

Một số đặc tính sinh học phân tử của vi khuẩn đường ruột mang gen New Delhi-Metallo-Beta-Lactamase (NDM-1) phân lập tại bệnh viện Việt Đức

Gram negative bacteria in the hospital environment carrying New Delhi-Metallo-beta-lactamase (NDM-1) gene conferring resitance to carbapenem

Y học Việt Nam

2013

2

169-173

1859-1868

Gram-negative bacteria resistance to carbapenems conferred by New Delhi metallo-beta-Iactamase 1 (NDM-1) gene are a major global health problem. NDM-1 can be detected in bacteria isolated from both clinical samples as a river in Vietnam. In this study, the authors therefore assessed the prevalence of NDM-1 gene in a hospital environment. Various environmental ssamples (ie, hand nurse, medical trolley, floor surface patient bed or toilet cover site) were collected from three surgery departments (urology, gastro-enterology and hepato-biliary surgery) in a Hanoi hospital. Samples were transported to the microbiology laboratory and tested for carabapenem resistance and subsequently the presence of the NDM-l gene by PCR. NDM-l positive bacteria were further identified by biochemical testing (API-20E strip, Biomerieux) and susceptibility testing. The results showed that, in September 2011, 200 swab samples were collected from different enviroments. the authors detected 5/200 (2.5 percent) samples positive with the NDM-l gene: three samples were patient bed sheet, one was from cover of medical binwash disposal, and one in toilet cover. The positive samples were from Urology and Hepato-biliary Surgery departments, which also had NDM-l positive patients detected prior to this study. The NDM-l gene was not found in any samples from Gastro enterology department. Three species, including A. baumanii, Acinetobacter spp and E. aerogenes carrying NDM-l gene were found. All of positive NDM-l were extensively drug resistant, but remained susceptible to colistin.

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